Synthesis, Characterize and Evaluation of anti-bacterial and anti-fungal activity of thiazines

Arsalan Sarmad,Razia Sultana,B Syed Salman

doi:10.33974/ijrpca.v1i1.26

Abstract

1,3 – Thiazines have been applied as useful starting materials in the stereo selective synthesis of compounds of pharmacological interest and they have served as chiral ligants and auxiliaries in enantioselective transformation. The thiazines are of great importance because they act as precursor for the synthesis of Cephalosporins (3,6-dihydro-2H-,1,3-thiazine) and then converted to the thiazine derivatives (an heterocyclic compounds). Therefore, it was thought to combine chalcones moiety to thiazine derivative together in a molecular frame work to see the biological activities, additive effort of these rings towards biological activities like Anti- bacterial and Anti- fungal activities.

Highlights

Thiazines a heterocyclic compound having four carbon atoms and one nitrogen atom and sulphur atom at varied positions in the six membered ring exist as 1,2- thiazine,1,3-thiazine and 1,4- thiazine and subsequently their derivatives having N-C-S linkage have been used as anti-tubercular, antibacterial, anti-microbial, anti-tumor, insecticidal, fungicidal, herbicidal agents, transquilizers and various dyes etc[5-7], anti-parkinsonian[8], calcium channel modulators, Anti- pyretic, antimycobacterial agents, Cannabinoid receptor agonists and Anti- Oxidant agents.The ability to treat bacterial infections which chemotherapeutic agents represents one of the most important medical achievement of the last millennium
The antibacterial activity of newly synthesized Chalcone or 2,6-dibenzylidene cyclohexanone and thiazine derivatives were evaluated against gram positive bacteria that is Staphylococcus aureus and Bacillus subtilis and gram-negative bacteria that is Escherchia coli and Pseudomonas aeruginosa
The zone of inhibition shown by the compound 2,6dibenzylidene cyclohexanone or Chalcone against Bacillius subtilis is 17 mm

Summary

Introduction

The ability to treat bacterial infections which chemotherapeutic agents represents one of the most important medical achievement of the last millennium. The emergence of microorganisms resistant to anti- bacterial agents has been continued to the present day. The latest twist to this increasingly alarming situation has been the recent isolation of methicillin resistant strains of Staphylococcus aureus. The first type is dermatophytoses caused by epidermaphyton species, microsporium species and tycophyton species consist of contagious superficial skin infections that are limited to the epidermal region. The second type is Candidiasis caused by Candida species can affect the skin, nails and mucous membranes and occasionally becomes systemic. The third type is subcutaneous, pulmonary, lymphatic and systemic mycoses caused by

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Discussion

Conclusion