Synthesis, characterization, thermal behavior and antimicrobial activity of 3-methyl benzoate complexes of transition metal with hydrazine

S Mohanapriya,Muthukumaran Muthukumaran,S Vairam

doi:10.4314/bcse.v30i2.8

Abstract

Reaction of the ligands, 3-methyl benzoic acid (mbH) and hydrazine with transition metal ions form the complexes of formulae, [M(N 2 H 4 ) 2 (mb) 2 ].H 2 O where M = Co(II) and Zn(II) at pH = 5-6, [M(N 2 H 4 ) n (mb) 2 ].xH 2 O where M = Ni(II), n = 2, x = 0 at pH = 5 and M = Cd, n = 1, x = 1 at pH = 6. The same acid also forms metal carboxylates with zinc and copper of formula, [Zn(mb) 2 H 2 O].H 2 O at pH = 6 and [Cu(mb) 2 ].H 2 O at pH = 5, respectively. The IR spectra of the complexes show that hydrazine is present as bridging bidentate ligand and the carboxylic acid as monodentate bridging carboxylate anion. The electronic spectra, magnetic moments and ESR spectral data suggest the coordination number. Thermal studies show that cobalt, zinc and nickel complexes containing hydrazine, and carboxylates of copper, zinc on their thermal decomposition form the corresponding metal oxides in nano size in the temperature range 755-815 °C. The antibacterial and antifungal activity show that both activities of the complexes are higher than that of the acid and among the complexes, cadmium compound shows more antimicrobial activity towards bacteria and fungi. KEY WORDS : Hydrazinium complexes, 3-Methyl benzoic acid, Thermal analysis, IR, Electronic spectra, Biological activity Bull. Chem. Soc. Ethiop. 2016 , 30(2), 241-252. DOI: http://dx.doi.org/10.4314/bcse.v30i2.8

Highlights

M-Toluic acid is an important chemical intermediate and is widely used to prepare insect repellents, polymer film former and thermal stabilizers for PVC
Preparation of [M(N2H4 )n(mb)2].xH2O where M = Co, Zn n = 2 and x = 1; M = Ni, n = 2 and x = 0; M = Cd, n = 1 and x = 1. These complexes were prepared by dissolving corresponding metal nitrate (1 mmol, for example Co(NO3)2 .6H2O; 0.2910 g in 20 mL of distilled water) and poured to ligand solution which was prepared by mixing 3-methyl benzoic acid (2 mmol, 0.2720 g) and hydrazine hydrate (4 mmol, 0.2 mL) in 60 mL hot water with constant stirring
The anti-bacterial and anti-fungal activities of the synthesized compounds were tested against various bacteria like Escherichia coli, Staphylococcus aureus, Salmonelle paratyphi, Bacillus substilis and fungus namely Candida albicans, Aspergillus niger, Aspergillus fumigate

Summary

Introduction

M-Toluic acid is an important chemical intermediate and is widely used to prepare insect repellents, polymer film former and thermal stabilizers for PVC. E-mail: vamshen@yahoo.com and anti-bacterial activity of metal complexes was higher than that of the parent carboxylic acids [18]. These complexes were prepared by dissolving corresponding metal nitrate (1 mmol, for example Co(NO3)2 .6H2O; 0.2910 g in 20 mL of distilled water) and poured to ligand solution which was prepared by mixing 3-methyl benzoic acid (2 mmol, 0.2720 g) and hydrazine hydrate (4 mmol, 0.2 mL) in 60 mL hot water with constant stirring.

Results

Conclusion