Abstract
New ligand containing 2-(2,4-dioxo-4-thiophen-2-yl-butyrylamino)-benzoic acid (HL) merged moiety was synthesized and characterized by FT-IR, elemental analyses, mass spectra and 1H-NMR spectral. In the present study, the attempts were carried to form complexes of HL ligand with some transition metal ions (MnII, CuII and CoII) of well-defined at the (1:1) ratio of the components in the dimethyl sulfoxide (DMSO) solvent. All complexes have been studied by FTIR spectra, elemental analyses, thermal analysis, molar conductivity, electronic spectra and magnetic moment. The HL ligand produced as a bidentate chelate with interactive metal ions. All the results suggested octahedral geometry to complexes and have the formulae [M(HL)(Cl)2(H2O)2].nH2O where M = Mn(II), Cu(II) and Co(II). The IR spectra of the complexes were assigned and compared with the data in literature. The kinetic and thermodynamic results such as E*, ΔH*, ΔS* and ΔG* were calculated based o the TGA/DTG curves using Coats and Redfern and Horowitz and Metzger approximation methods. Furthermore, the resultant complexes were evaluated for the anti-bacterial and anti-fungal potential.
 
 KEY WORDS: 2-(2,4-Dioxo-4-thiophen-2-yl-butyrylamino)-benzoic acid, Transition metal complexes, FTIR, TGA, Antimicrobial test
 
 Bull. Chem. Soc. Ethiop. 2021, 35(1), 129-140.
 DOI: https://dx.doi.org/10.4314/bcse.v35i1.11
Highlights
Anthranilic acid is a viable substitute for the amino acid as a ligand
The literature survey show that the complexes of rhodium with anthranilic acid and N-phenyl anthranilic acid can act as catalysts for hydrogenation [5], terbium(III) complexes of anthranilic acid can appear the photoluminescence properties [6], a model into a peroxidase inhibitor complex [7]
The signal at 12.419 ppm is assigned to the proton of –NH group and the aromatic signals are significantly exhibited with the range of 7.207-8.759 ppm, while the signal appeared at 4.631 ppm is assigned to methylene group –CH2 which flanked between two ketonic group
Summary
Anthranilic acid is a viable substitute for the amino acid as a ligand. It is an amino acid analogue containing carboxyl and amino groups as well as high electronegativity oxygen and nitrogen atoms capable of coordinating transition metals. Several other mixed ligands complexes with anthranilic acid were reported to have antifungal and antibacterial potential [11]. The antibacterial activities of the investigated compounds were tested against Escherichia Coli and Staphylococcus aureus as well as some kinds of fungi; Aspergillus flavus and Candida albicans.
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