Synthesis, Characterization, Structural Interpretation, Biological Activity and DNA Cleavage Studies of 3-acyl 2-(2’hydroxy-5-X phenyl) Benzothiazoline Cu (II) Complexes

Abstract

Benzothiazolines and other compounds containing –NC6H4Sare reported to have biological activity. The ligand 3-acyl 2-(2’hydroxy-5-X phenyl)benzothiazoline (X=H, Cl, NO2, OCH3) forms complexes [Cu(L-H)] which have been characterised by various spectro-analytival techniques such as elemental analyses, magnetic moments, molar conductance, electronic, mass, ESR, TGA and IR spectral measurements. Room temperature ESR spectra of Cu(II) complexes inferred ‘g’ values characteristic of square planar geometry and square pyramidal geometry. The QSAR and molecular properties of title compounds were computed by employing HyperChem 7.5 tools. The title compounds and their corresponding Cu(II) complexes were assayed by the agar disk diffusion method for antibacterial and antifungal action against E. coli, S. marcescens, P. aeruginosa, S. aureus, B. Subtilis and C. Albicans respectively. The DNA cleavage studies on PBR322 DNA indicated the hydrolytic cleavage by Cu (II)-AHNPBT, wherein super coiled DNA (form I) is converted into relaxed and linear DNA (form II & form III).