Synthesis, characterization, solution chemistry and anticancer activity of [NiCl2(Ph2P–N(R)–PPh2)] (R = 2-CH2Py, CH2Ph and p-tol) complexes

Abstract

In this work three Ni2+ complexes with general formula [NiCl2(Ph2P–N(R)–PPh2)], R = 2-CH2Py (Py = pyridine) – 1, CH2Ph (Ph = phenyl) – 2 and p-tol (p-tol = p-tolyl) – 3, were synthesized and characterized. These complexes were obtained in high yield by the reaction of NiCl2.6H2O and the corresponding diphenylphosphinoamine ligand (Ph2P–N(R)–PPh2) in CH2Cl2/MeOH (1:1) solution, at room temperature (∼25 °C), and characterized by 1H and 31P {1H} NMR, vibrational spectroscopy in the infrared region, electronic spectroscopy in the UV–Vis regions, elemental analysis (%C, %H, %N) and single-crystal X-ray diffraction. The solution chemistry was studied in CDCl3/dmso-d6 (dimethylsulfoxide) or neat dmso-d6 using complex 2 as a model. The complexes were evaluated as cytotoxic agents against two cancer cells lines, A549 (lung cancer cells), B16F10 (melanoma cells) and the health cells HaCaT (human epithelial keratinocytes).