Abstract
Bis(pyridinium)amine 4,4'-[(2-aminophenyl)azanediyl]bis(1-methylpyridin-1-ium)triflate ([H2L][TfO]2) was synthesized and characterized by elemental analysis, UV–Vis, fluorescence, FT-IR, 1H, and 13C NMR spectroscopies, mass spectrometry, and a single crystal X-ray structure analysis. The potential of the title compound to interact with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) was investigated with the help of UV–Vis, florescence and docking studies. UV–Vis spectroscopy indicated that the binding of [H2L][TfO]2 with CT–DNA took place via a groove binding mode. [H2L][TfO]2–BSA was characterized by moderate binding constant, electrostatic interaction and spontaneous association. [H2L][TfO]2 Displayed excellent enzyme inhibition activity with Trypsin and acetylcholine esterase. [H2L][TfO]2 was found to be an efficient antioxidant, scavenging the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) in a dose dependent manner. [H2L][TfO]2 exhibited activity against six microbes selected for the study.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
