Abstract
In our present study, we focused our attention on the synthesis of (S, E)-4-(4-(2-(4-substitutedbenzylidene) hydrazinyl) benzyl) oxazolidin-2-one (7-11) via (S)-4-(4-hydrazinylbenzyl) oxazolidin-2-one (1) with substituted aryl benzaldehydes (2-6). The structures of the compound were spectrally determined Elemental analysis data like FTIR, NMR (1H & 13C). An estimate of the pharmacological potential (antimicrobial, antioxidant and anti-inflammatory) of the compound synthesized was made on a PASS (Prediction of Activity Spectra for Substances) basis. Interestingly, PASS 7-11 compound forecasting showed that none of the synthesized compounds act as antifungal agents compared with standard ascorbic acid, but that the synthesized compositions can do much better in anti-inflammatory than antibacterial and antioxidant. Moreover, these compounds were subject to the silico ADMETox (absorption, distribution, metabolism and excretion) assessment and all compounds were examined for ADME and only few compounds compared to standard passed the predicted toxicity assessment. This work can help identify potential new molecules with promising activity and low toxicity as an initial approach.
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