SYNTHESIS, CHARACTERIZATION OF SOME SUBSTITUTED BIPHENYL-2- AMINOTHIAZOL DERIVATIVES

Abstract

The synthesis explored to serve novel functional group extended Anti-microbial bio-active molecules of substituted Aminothiazoles. It reveals from overall available up to date literature feedback of Aminothiazoles, it is difcult to synthesis of substituted biphenyl-2-aminothiazoles from Suzuki coupling reaction of 5-(4-bromophenyl) thiazol-2-amine with substituted Boronic acids in presence of Palladium (II) acetate catalyst and in 5% aqueous Isopropyl alcohol used as a solvent. This is a shortest pathway to synthesis of biphenyl derivatives of Aminothaizoles by Suzuki coupling method.