Synthesis, characterization of new 5-(4-nitrophenyl)-4-((4 phenoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol metal complexes and study of the antibacterial activity

Abstract

A new Schiff base ligand(HL) was synthesized by condensation of 4-amino-5-(4-nitrophenyl)-4H-1,2,4-triazole-3-thiol with 4-phenoxybenzaldehyde. A new three metal complexes Zn (II), Cd (II) and Hg (II) with Schiff ligand (HL) ware synthesized by molar ratio of ligand : metal as 2:1. The ligand and metal complexes were characterization by H1-NMR, FT-IR, Atomic absorption, CHNS analysis, molar conductivity magnetic susceptibility and melting point. There are study thermal analysis TGA-DTG for the ligand and metal complexes. All complexes were found to be non-electrolyte. The biological activity (antibacterial) in-vitro are investigated for the complexes at prepared concentration (1*10-3 M) and showed inhibition ability against growth of the four types of pathogenic bacteria: [Staphylococcus aurous. and Streptococcus sp.] as gram positive and [Escherichia coli and Pseudomonas aeruginosa] as gram negative. The most of these complexes are effective against both types of bacteria in varying degree, with high activity for Hg (II) complexes.