Abstract
New chlropheniramine maleate (CPM) selective electrochemical membranes were prepared by using chlropheniramine maleate -molecularly imprinted polymers. MIP was prepared by bulk polymerization using 2-hydroxyethyl methacrylate (2-HEMA) as monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker and a benzoyl peroxide (BPO) as an initiator at 600C. Three CPM-MIP electrodes were constructed by using tri-tolyl Phosphate (ToCP), tris (2- ethyl hexyl) Phosphate (TEHP) and tributyl Phosphate (TBP) as plasticizers in PVC matrix.Electrode parameters including slopes, working concentrations ph. The interference effect in the presence of (Na+, Mg+2, Al+3, Glycine, Alanine, Arginine and Phenylalanine) was studied using the separated and mixed methods to determine the selectivity coefficient determination. NIP prepared by using the same composition of MIP molecularly imprinted polymer electrodes except the template (CPM). The slopes of CMPMIP are 21.00, 21.50 and 19.08 mV/ decade, linearity range for the electrodes around. (10-5 10-1) M, the stable at a pH range from 4.0 to 8.5 and lifetime ranged from 30 to 10 days. The suggested electrodes were successfully applied for the determine of CPM in some pharmaceutical preparations, which were given acceptable accuracy.
Highlights
Chlorpheniramine maleate tablets made by Manfei et al and used as samples for analysis using near infrared chemical imaging to acquire the concentration information of CPM coupled with partial least squares for quantitative analysis of CPM [11]
Recent Molecular imprinted polymers (MIPs) was reviewed by Jesika et al [15] including the previous and current literature regarding the analytical tools employed for synthesized MIPs
Chlorpheniramine maleate imprinted polymers MIP and CPM were recorded in the range of (400–4000) cm-1 by the KBr pellet method
Summary
Several papers were published in electrochemical by preparing electrodes based on MIP for drug determination. Al-Bayati [19] prepared ibuprofen MIP using methacrylic acid as monomer with different plasticizers and determined ibuprofen in pharmaceutical samples. In this study the chlorpheniramine maleate imprinted polymer sensors were prepared using different plasticizers in PVC matrix by polymerization with 2-
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