Abstract
Curcumin-Fe(III) complex was prepared from Fe(NO3)3 ·9H2O precursor and curcumin by refluxing a slightly basic methanolic solution of their mixture with the objective of investigating its cytotoxicity. The enol form of curcumin ligand was established by FTIR, UV/Vis, 1H NMR, and 13C NMR spectroscopy. The as-prepared product was characterized by elemental analysis, FTIR, UV, and Mössbauer spectroscopic techniques. An octahedral high-spin Fe(III) complex was obtained, δ, 0.37 mms−1; Q.S., 0.79 mms−1; no magnetic relaxation was observed at liquid N2 temperature, neither reduction of Fe(III). The tested cytotoxicity of the as-prepared complex on four cancer cell lines indicated inhibition of the curcumin activity upon complexing with iron.
Highlights
The β diketone curcumin and curcuminoids (1,7-diaryl1,6-heptadiene-3,5-diones) which are a group of naturally occurring 1,3-diketones have received considerable attention in the last few decades
It is demonstrated that the coordination of metal ions, for example, Cu(II), Mn(II), Au(III), and so forth, with bioactive ligands can improve the pharmaceutical activity of drugs [6, 7]
In this paper we report the Mossbauer data of Fe(curc)3 complex, compare it to the well-known Fe(acac)3 data, and identify and correlate oxidation state of the central iron metal ion, magnetic relaxation, and structural symmetry of the as-prepared complex to its antitumor cytotoxicity on four cancer cell lines
Summary
The β diketone curcumin and curcuminoids (1,7-diaryl1,6-heptadiene-3,5-diones) which are a group of naturally occurring 1,3-diketones have received considerable attention in the last few decades. This is due to the fact that they possess antitumor [1,2,3] and antioxidant effects [4] and have a good potential for metal ions complexation. In this paper we report the Mossbauer data of Fe(curc) complex, compare it to the well-known Fe(acac) data, and identify and correlate oxidation state of the central iron metal ion, magnetic relaxation, and structural symmetry of the as-prepared complex to its antitumor cytotoxicity on four cancer cell lines
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