Abstract
Objectives: To synthesize 2-furan-2-ylmethyleneamino-phenyl-iminomethylphenoland its complexes and evaluate the anticancer activity of the ligand and complexes against breast cancer cells. Methods/Statistical Analysis: A novel compounds have been synthesized and characterized by many spectral and DFT measurements. The molecular structural parameters of the synthesized furan-Schiff base ligand HL ligand and its isolated metal(II) complexes have been calculated. Anticancer activity for the ligand and the complexes were evaluated against breast cancer cells by using MTT assay. Findings: The microanalytical data of the isolated compounds are in good agreement with the calculated values and the spectroscopic analysis of the isolated complexes indicated that the HL ligand coordinated to the metal centers as tetra dentate ligand and form octahedral arrangement around metal(II) centers. The molecular parameters of the ligand and its metal complexes have been calculated and correlated with the experimental data such as IR and TGA results. The results of cells MCF7 breast cancer revealed of cell proliferation was much more highly inhibited by the HL ligand and its isolated complexes Co(II), Ni(II), Cu(II) and Zn(II) with cell viability 24.82, 58.9, 62.7, 73.8 and 87.3%, respectively at a concentration of 1000 PPM compared to untreated control cells. Application/Improvements: Lastly, some suggestions were presented to use these isolated compounds in vivo should be assessed to obtain worthy anticancer drugs. Keywords: Anticancer Activity, Characterization, Isolated Complexes, Molecular Structures, IR, TGA
Highlights
Azomethine Schiff neither base ligands containing more than one do nor are sites extensively used for the preparation of metal ion complexes with interesting properties
Transition metal (II/III/IV) complexes of these ligands containing pyridine, furan rings and their derivatives are of great interest due to their ability to absorb visible light to act as electron reservoirs are promising factors in their applications as photosensitizers1–3
The FT-IR spectrum (Table 2) of 2-furan-2-ylmethyleneamino-phenyl-iminomethyl- phenol is given in synthetic procedures
Summary
Azomethine Schiff neither base ligands containing more than one do nor are sites extensively used for the preparation of metal ion complexes with interesting properties. Transition metal (II/III/IV) complexes of these ligands containing pyridine, furan rings and their derivatives are of great interest due to their ability to absorb visible light to act as electron reservoirs are promising factors in their applications as photosensitizers. Azomethine (CH=N) Schiff bases are considered to be the most important legends in coordination chemistry. They are used as catalysts, dyes and pigments, intermediates in organic synthesis and as polymer stabilizers. Azomethine (CH=N) Schiff bases have been utilized in the synthesis of a number of industrial and biologically active compounds such as formazans, benzoxazines, and so on. Azomethine (CH=N) Schiff bases and their complexes
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