Abstract
In this study, two new Schiff base compounds (4 and 5) based on substituted salicyl aldehyde were synthesized. The structures of the synthesized compounds were determined by FT-IR and 1H(13C) NMR spectroscopies. The AChE inhibition activities of the compounds were investigated. According to the results obtained, the activities of compounds 4 (IC50: 1.396 ± 0.35 M) and 5 (IC50: 0.795 ± 0.47M) were found to be significantly effective than Tacrin (TAC) (IC50: 166.10 ± 17.53 M) (currently used drug). The interaction types and binding energies of compound 5, which has higher activity, were investigated by molecular docking studies.
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