Abstract
Metal complexes were prepared by the reaction of thiosemicarbazone with CuCl2, NiCl2, CoCl2, Cu(OAc)2, Ni(OAc)2, and Co(OAc)2. The thiosemicarbazone coordinates to metal through the thionic sulfur and the azomethine nitrogen. The thiosemicarbazone was obtained by the thiosemicarbazide with 3-acetyl-2,5-dimethylthiophene. The identities of these compounds were elucidated by IR, 1H, 13C-NMR, and GC-MS spectroscopic methods and elemental analyses. The antibacterial activity of these compounds was first tested in vitro by the disc diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined by using chloramphenicol as reference drug. The results showed that compound 1.1 is better inhibitor of both types of tested bacteria as compared to chloramphenicol.
Highlights
Most of the tropical and subtropical regions of the world are suffering from parasitic diseases
Thiosemicarbazone derivatives form an important class of organic compounds due to their structural chemistry and biological activities, such as antibacterial, antivirus activities
Heterocyclic sulfur and oxygen containing thiosemicarbazones have been the subjects of extensive investigation because of their use for the biological applications [6, 7]
Summary
Most of the tropical and subtropical regions of the world are suffering from parasitic diseases. Cu(II), Ni(II), and Co(II) metal complexes of thiosemicarbazone dramatically increase the biological activities such as antibacterial, antifungal, anti HIV, and anti-inflammatory [12] Thiosemicarbazones and their metal complexes are applicable in the field of material sciences such as nonlinear optical (NLO) [13], electrochemical sensing [14], and Langmuir film [15]. Metal thiosemicarbazone complexes are promising as new class of experimental anticancer chemotherapeutic agents which shows evidence of inhibitory behavior against cancer [21]. These are a useful model for bioinorganic processes [22, 23]. Due to wide range of application of the thiosemicarbazones and their metal complexes, we have synthesized, characterized, and studied the antibacterial activity of thiosemicarbazone and its Cu(II), Ni(II), and Co(II) metal complexes
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