Abstract
A series of N-[4-(Nitrophenoxy)phenyl]alkanamides (N-1 to N-14) with different alky groups were synthesized following two-step procedures. The structural elucidation of the synthesized compounds was carried out by IR and NMR spectroscopic techniques along with elemental and single crystal X-ray diffraction analyses. Molecular docking study (drug-DNA binding) was carried out to check their biological potential. The docking data revealed the interaction of compounds with ds. DNA, which was further complemented by cyclic voltammetric study. The synthesized compounds showed minor groove binding mode of interaction with DNA. The increased chain length of alkyl groups did not significantly affected the compound-DNA binding.
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