Abstract
Interaction of chiral Ru(II) salen complexes ( S )-1 and ( R )-1 with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, CD measurements, thermal denaturation study and cleavage studies by agarose gel electrophoresis. The DNA binding affinity of ( S )-1 (6.25 × 10 3 M −1) was found to be greater than ( R )-1 (3.0 × 10 3 M −1). The antimicrobial studies of these complexes on five different gram (+)/(−) bacteria and three different fungal organisms showed selective inhibition of the growth of gram (+) bacteria and were not affective against gram (−) and fungal organisms. Further, the ( S )-1 enantiomer inhibited the growth of organisms to a greater extent as compared to ( R )-1 enantiomer.
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