Abstract
Two series of novel thiazolylcarboxamide derivatives were synthesized by the reaction of ethyl 2-amino-4-methylthiazole-5-carboxylate or 1-(2-amino-4-methylthiazol-5-yl)ethan-1-one with four substituted carbonyl chlorides at 0 °C in excellent yield. All products were characterized by FTIR, 1H NMR spectroscopy and mass spectrometry. Crystal structures of four compounds were studied by X-ray analysis. All the synthesized compounds were screened against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes for antibacterial activity and against Candida albicans, Aspergillusniger and Aspergillus clavatus for antifungal activity. Present study describes the biological activity and crystal structure study of carboxamides obtained from 2-aminothaizol derivatives. Owing to the insolubility of these amides in single volatile solvent, crystals were grown in a mixture of solvents.
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