Abstract
A new Cd(II) complex with the ligand 4′-chloro-2,2′6′,2′′-terpyridine (Cltpy), [Cd(Cltpy)(I)2], has been synthesized and characterized by CHN elemental analysis, 1H-NMR, 13C-NMR, and IR spectroscopy and structurally analyzed by X-ray single-crystal diffraction. The single-crystal X-ray analyses show that the coordination number in complex is five with three terpyridine (Cltpy) N-donor atoms and two iodine atoms. The antibacterial activities of Cltpy and its Cd(II) complex are tested against different bacteria.
Highlights
Terpyridine molecules with three nitrogen atoms acting as tridentate ligands to coordinate with various transition metal ions have been extensively studied [1, 2]
In this research we used new tridentate ligand 4 chloro-2,2 :6,2 -terpyridine (Cltpy) that has been used for synthesis of a new cadmium(II) complex
It is should be noticed that the antibacterial activity of Cltpy ligand is higher than standard antibiotic against Pseudomonas aeruginosa, Streptococcus pyogenes, and Klebsiella pneumonia
Summary
Terpyridine molecules with three nitrogen atoms acting as tridentate ligands to coordinate with various transition metal ions have been extensively studied [1, 2]. The 4 -chloro-2,2 :6 ,2 -terpyridine (Cltpy) ligand (Figure 1) contains one widely used tpy coordinative site and the other Cl site at the 4 -position These two sites are able to bind with different metal ions, leading to the coordination polymers with various frameworks [21]. The synthesis of tpy derivatives has been extensively studied by Constable’s group, and varieties of substituted tpy compounds have been reported [19, 20] They offered interesting prospects for metal-activated drug delivery system, where the activity could be switched by metal-ion coordination through the study of the interactions between bioreceptors and ligand with sugar substituents [19, 20]. The structural and biological properties of this new complex have been studied
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