Synthesis, characterization, coordination chemistry and biological activity of some pyrimidine complexes

Abstract

A group of biologically active ligands: 5-(2hydroxyphenylide) barbituric acid (L1), 5-(phenyl azo) thiobarbituric acid (L2) and 5-(phenyl azo) barbituric acid (L3) and its complexes with Os(VIII), Ru(III),Zr(IV) and V(III) ions were synthesized. The chemical structures of these compounds were fully identified using MALDI-TOF, FT-IR,1H NMR, TGA and DSC techniques, magnetic susceptibility measurements helped to determine the exact geometry of the complexes under study. The dissociation constants of the ligands were evaluated by analyzing their electronic absorption spectra at different pH’s. All the compounds were tested for its anticancer, antimicrobial and antioxidant activities.The collected data showed that some of the compounds can be used as drugs for the treatment of breast cancer (MCF-7 cancer cells) and as potent antibiotics for both gram-positive and gram –negative bacterial species including: Staphelococcus Epidermisis, Escherishia Coli,Staphyllococcus Auresis and Salmonilla and the fungal species: Candida Albicans. The DPPH Radical Scavenging Activity of the compounds showed that most of the compounds can be used as good antioxidant agents.