Abstract
A new quinazolinone derivative namely 2‐(4‐phenylpiperazinyl)methyl‐3‐(8‐quinolinol‐5‐yl)‐ 4(3h)‐quinazolinone(HL) was prepared and characterized. Various transition metal (Cu2+, Co2+, Ni2+, Zn2+, Mn2+) chelates of HL were prepared and characterized by metal ligand (M:L) ratio, IR and reflectance spectral studies, magnetic moment, and antimicrobial activity.
Highlights
Report shows that various scientists investigated the quinazolone derivatives as biological and pharmaceutical agents[1,2,3,4,5,6]
It was aimed to explore the field of quinazolone-8-hydroxy quinoline combined molecules
Synthesis 2-chloromethyl-3-(8-quinolinol-5-yl)-4-3(H)(quinazolinone): A mixture of N-chloroacetyl anthranilic acid( 0.1 mole) and 5-amino-8-quinolinol (0.1 mole) and PCl3 (0.1 mole) in dry toluene was refluxed under anhydrous condition for 9 hours
Summary
Report shows that various scientists investigated the quinazolone derivatives as biological and pharmaceutical agents[1,2,3,4,5,6]. Synthesis 2-chloromethyl-3-(8-quinolinol-5-yl)-4-3(H)(quinazolinone): A mixture of N-chloroacetyl anthranilic acid( 0.1 mole) and 5-amino-8-quinolinol (0.1 mole) and PCl3 (0.1 mole) in dry toluene was refluxed under anhydrous condition for 9 hours. The precipitate of metal chelates were filtered off, washed and air-dried.
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