Abstract
Polyamidoamines were synthesized by Michael-type polyaddition reaction and conjugates characterized by 1H NMR, 31P NMR, FTIR, SEM, and EDX. The biological evaluation of the new materials revealed 12–30% inhibition of the human breast cancer cells (MCF7) and 25% of the Plasmodium falciparum malaria parasites by the conjugates. The hemolysis assay revealed that these materials did not have any effect on the host red blood cell membrane. The release mechanism of neridronate followed Korsmeyer–Peppas model at pH 1.2 with a diffusion coefficient of 0.45 indicating a Fickian diffusion mechanism; Higuchi model at pH 6.0 thus indicating a diffusion mechanism.
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