Synthesis, Characterization, Antimicrobial and Antimalarial Activities of 5-((2- phenylacetoxy) carbonyl)-1H-pyrazole-3-carboxylic Acid and its Ce(III), Pr(III) and Nd(III) Complexes

Abstract

In the past decade, the lanthanoid coordination chemistry was one of the most focused areas of research due to their wide applications as catalyst, magnetism, luminescence and diagnostic tools in biological studies. In this study, novel pyrazole; 5-((2-phenylacetoxy) carbonyl)-1Hpyrazole-3-carboxylic acid derivative and its lanthanoid complexes are designed and tested for potential antimicrobial and antimalarial activities. The binuclear ligand bridge complexes were obtained by the interaction of the ligand with the lanthanide salts. The compounds were characterized by 1H and 13C nuclear magnetic resonance (NMR) spectroscopy, UltravioletVisible spectroscopy, Fourier Transform infrared (FT-IR) spectroscopy, Mass spectrometry (MS), Elemental analysis and Magnetic susceptibility measurements. The in vitro antimicrobial assay was done by Agar well diffusion method and in vivo antimalarial studies were performed based on Peter’s method. The results were analysed using one way analysis of variance (ANOVA). The antimicrobial and antiparasitic effects of these compounds were found to be dose-dependent and they showed greater effects at higher doses.&nbsp