Abstract
The 1:2 chelation behavior of the cimetidine (cim) anti-ulcer drug towards three metal ions of tungsten (VI), silicon(IV) and hafnium (IV) was investigated. The synthesis and characterizations of [M(cim)2].xCl2 (where M = W, Si or Hf; x = 2 for Si or Hf and x = 3 for W) were discussed. The cim ligand acts as tetradentate N(3) imidazole, S(8) thioether, N(11) secondary amine and the N-nitrile group seems to be involved in the complexation. The microanalytical, magnetic, conductance, FTIR, UV-visible, XRD, 1H-NMR spectral studies, were employed for the characterization. The inhibition activity of drug ligand and its metal ion complexes was evaluated towards different types of bacteria and fungi through in vitro antimicrobial activities. The antitumor activity of silicon(IV) complex is straightened towards human liver carcinoma (HepG-2) cell lines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
