Abstract
Vanadium complexes have been synthesized by the reaction of mercapto methyl benzimidazole with carbon disulphide and then with different vanadium salts in different M L ratio The synthesized vanadium complexes have been characterized by elemental microanalysis CHN FT IR spectroscopy and NMR H C spectroscopy Elemental analysis data shows good agreement between found and calculated values FT IR spectroscopic data suggests the bidentate nature of the ligand The results of multinuclear NMR revealed that coordination occurs through NCS moiety Antibacterial activity data showed that ligand and complexes showed moderate antibacterial and anti biofilm activity The cytotoxicity studies showed that vanadium complex is less cytotoxic and complex has maximum cytotoxicity In vitrooxidative DNA damage protection assay showed that synthesized vanadium complexes exhibited plasmid DNA protection by scavenging the oxidation products Results of in vitro anticancer activity showed that oxoperoxo vanadium complex exhibited significant anticancer activity IC mu M against H MX cell line
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