Synthesis, Characterization, Anti-bacterial and Anti-inflammatory Activities of Bismuth(III) Complexes Based on 5-chloro-2-mercaptobenzothiazole

Abstract

Bismuth, known as a heavy metal, is excluded from this class due to its low toxicity. Due to this feature, bismuth containing compounds have always been interesting compounds in the field of medicinal chemistry. For this reason, the discovery of new bismuth compounds and the investigation of their biological properties are very important for this field. In this study, three new bismuth(III) compounds formulated as [Bi(L)2X3] (L: 5-chloro-2-mercaptobenzothiazole (ClMBZT); X: Cl, Br, and I) were synthesized for the first time and, the molecular structure of them were elucidated by a series of spectroscopic techniques. Thermal stability and degradation steps of the title compounds were analyzed by Thermogravimetric-Differential Thermal Analysis (TG-DTA). The antibacterial study has been conducted against six strains bacteria, and the results indicated that bismuth(III) compounds generally showed more effective antibacterial activity than free ligand. The anti-inflammatory potential of bismuth(III) compounds was investigated through in vitro lipoxygenase enzyme inhibition studies. The results show that bismuth(III) compounds have higher anti-inflammatory potential than free ligand.