Synthesis, characterization and XRPD studies of the bioactive complex of 2-hydroxy-3,5-dimethyl acetophenoneoxime (HDMAOX) with oxovanadium(IV)

Abstract

The complex of 2-hydroxy-3,5-dimethyl acetophenoneoxime (HDMAOX, HL) with VO(IV) has been synthesized and characterized by different physical techniques. Infrared spectra indicate deprotonation and coordination of the phenolic OH, and nitrogen of the oximino group. Electronic spectra and magnetic susceptibility measurements support square-pyramidal geometry around the metal ion. The elemental analyses and mass spectral data indicate ML2 composition. Thermodynamic activation parameters were computed from the thermal data using the Coats and Redfern method. The crystal data for C20H24N2O5V are: tetragonal, space group P4/m, a = 11.76975 Å, b = 11.76975 Å, c = 18.89209 Å, V = 2617.06 A3, Z = 4. The free ligand (HDMAOX) and its oxovanadium complex have been tested in vitro against Alternaria alternate, Aspergillus flavues, Aspergillus nidulans and Aspergillus niger fungi and Streptococcus, Staph, Staphylococuss and Escherchia coli bacteria in order to assess their antimicrobial potential. The results indicate that the ligand and its metal complex have antimicrobial properties.