Abstract
The synthesis of a series of 2-(3,5-dimethylpyrazol-1-yl)phenyl-based organoselenium compounds, (dmpzC6H4Se)2 (1), dmpzC6H4SeR (dmpz = 3,5-dimethylpyrazol-1-yl; R = (CH2)nY; Y = OH, NH2, and COOH), and dmpzC6H4SeX (X = Cl, Br, or I) is described. The compounds are characterized by IR, NMR (1H, 13C{1H}, 77Se{1H}), and mass spectral (MS) data. The molecular structures of (dmpzC6H4Se)2, dmpzC6H4SeCH2COOH, and dmpzC6H4SeCH2CH2OH have been established by X-ray crystallography. The two latter compounds are associated in the solid state through intermolecular hydrogen bonding between the OH proton and the pyrazolyl nitrogen atom of the adjacent molecule. Glutathione peroxidase (GPx) like catalytic activity of these compounds has been evaluated by using hydrogen peroxide (H2O2) as substrate and dithiothreitol (DTTred) as thiol cofactor in CD3OD, and the progress of the reaction was monitored by 1H NMR spectroscopy. All the compounds exhibited the GPx-like catalytic activity. Among these, the ones containing alkylamino groups showed the best activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
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