Synthesis, characterization and tumor cell growth inhibition of new trans platinum complexes with phosphane derivatives

Abstract

We have reported the synthesis and characterization of two new trans platinum complexes in the phosphane series, where the phosphane ligand is triphenylphosphine [P(Ph) 3] and the group in the trans configuration is represented by chiral aliphatic amines, (racemic in complex 1 and S–NH 2CH 2CH(CH 3)CH 2CH 3 in complex 2). The anti-proliferative activity detected in tumor cells treated with the two new complexes is more pronounced when the aliphatic amine is racemic compared to the S-enantiomer. Moreover, for both compounds, the activity is fast after cell exposure and, unlike that of cisplatin, virtually independent of the duration of cell challenge.