Abstract
A novel magnetic nanocomposite with enrofloxacin (ENR) intercalated MgAl layered double hydroxides (LDH) coated on Fe3O4 particles, denoted as Fe3O4@(ENR–LDH), was assembled via a delamination–reassembling process. Fe3O4@(ENR–LDH) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, element chemical analysis, transmission electron microscopy, differential scanning calorimetry, and room-temperature magnetic measurements. Results showed the following: ① Fe3O4@(ENR–LDH) consisted of both ENR–LDH nanocrystallite and Fe3O4 phases; ② Fe3O4@(ENR–LDH) presented well-defined core–shell structure with diameter in the range of 15–20nm; ③ the thermal stability of ENR was enhanced after intercalation; and ④ Fe3O4@(ENR–LDH) exhibited good superparamagnetism. The release kinetics of ENR was investigated in buffer solutions at pH4.6 and 7.2, and the release process fitted Bhaskar model indicating diffusion-controlled mechanism. In addition, ENR release rate from Fe3O4@(ENR–LDH) was remarkably lower than that from the corresponding physical mixture, showing that Fe3O4@(ENR–LDH) can be considered as a potential magnetic targeting drug delivery-controlled-release system.
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