Abstract
This study includes formation Schiff bases compounds [A1- A3] were synthesis from raction4-aminoantipyrine with many aromatic aldehydes [4- chloro benzaldehyde, 4-bromo benzaldehyde and 2-hydroxy1-naphthaldehyde] in absolute ethanol. These compounds [A1-A3] has been characterized by melting points, [FT.IR] spectroscopy, thin layer chromatography technique (TLC) has been used for reactions steps and sequence by using solvent (ethyl acetate:toluene, 1:4). Antibacterial activity test was done according to agar well diffusion method against two types of multi-drug resistance of bacteria isolated from patients with infection of urinary tract. Three concentrations were prepared for each compound (50, 100 and 150) mg/ml. The results proved that derivative compound A3150 mg/ml provided the best antibacterial activity against K.pneumoniae with inhibition zone diameter 21± 0.25mm and against C.freundii 22± 0.5mm as compared with other derivatives compounds.
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