Synthesis, characterization, and some metal complexes incorporating 4-chlorobenzaldimine 4-aminoantipyrine and 2-aminophenol in antimicrobial activity

Abstract

Metal complexes of Schiff base (L) ligand, prepared via condensation of 4-chlorobenzaldimine 4-aminoantipyrine, and 2-aminophenol are prepared. The ligand is characterized based on elemental analysis, Mass, IR, and NMR spectra. Metal complexes are reported and characterized based on elemental analyses, IR, electronic spectra, magnetic moment, molar conductance and cyclic voltammetry (cv). From the elemental analyses, 1:1[M]:[Ligand] complexes are prepared with the general formulae [M(L CL) (M=Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)). The IR results demonstrate that coordination sites are the two azomethine nitrogen and hydroxyl oxygen atoms. The electronic spectral and magnetic measurement data indicate that the complexes exhibit tetra geometry and Cu(II) exhibits distorted square planar around the metal centre. The in vitro biological screening effects of the synthesized compounds were tested against various microbial species and the results show that the metal complexes are more biological active than the ligand. The DNA cleavage activity of the ligand and its complexes were assayed on pUC18 DNA using gel electrophoresis. The result shows that the Co(II) and Cu(II) complexes have completely cleaved the DNA.