Abstract
A series of N-arylfluorinated hydroxylated-Schiff bases were synthesized in a facile and high yield manner. The compounds were fully characterized including the unequivocal determination of the structure of two derivatives (2 and 4) by single crystal X-ray diffraction analysis. Preliminary in vitro antiparasitic activity against an endemic Trypanosoma cruzi strains in Mexico (NINOA) showed these compunds to have better trypanocidal activity compared to the reference drugs Nifurtimox (Nfx) and Benznidazole (Bnz).
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