Synthesis, Characterization and Preliminary Antimicrobial and Antiinfl ammatory Evaluation of New Ibuprofen Hydrazide Derivatives

Abstract

Non-steroidal anti-infl ammatory medicines (NSAIDs) are medicines that are distributed widely across the world due to their ability to reduce pain and infl ammation. In order to boost the drug’s effi cacy and reduce its harmful side eff ect like GIT ulcers and bleeding, a newly synthesized series of 25-(1-(4-isobutylphenyl) ethyl)-1,3,4-oxadiazole-2-thiol derivatives compounds (C, C 1-3) were prepared from the reaction of ibuprofen hydrazide with carbon disulfi de followed by reaction with various Aryl/ alkyl halide. All target compounds were tested for antimicrobial effi cacy against various strains of bacteria (G+ve, S. pyrogenes and S. aureus) and (G-ve, E. coli and 1Klebsiella pneumoniae). Additionally, fungus species (Candida albicans). Compound C showed good antimicrobial activity for both bacterial strains. At the same time, Compound C1 have the best ant-bacterial activity compared with other synthesized compounds for1 both (G+ve), and (G-ve) bacteria, and compound C3 was the most aff ected one as antifungal. The compound C2 was with lowest antimicrobial activity. All of the produced compounds were examined for their anti-infl ammatory activity using (egg-white generate edema) and the compounds (C, C1, C3) showed good effi cacy when compared to ibuprofen (stander) FTIR and 1H-NMR spectroscopy were used to analyze all of the fi nal products.