SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL SCREENING OF SOME NOVEL BENZIMIDAZOLE DERIVATIVES

Abstract

The reaction of o - phenylenediamine with anth ranillic acid yield compound 2 - (1H ben zo[d]imidazol - 2 - yl) aniline ( 1 ). The compou nd ( 1 ) was condensed with Chloro acetyl chlorides in the presence of dry benzene to get compound 2 - chloro - N - [2 - (2,3 - dihydro - 1 H benzimidazol - 2 - yl)phenyl]acetamide.Further it to then treated with KSCN to getan intermediate compound then reacted with correspond ing aromatic aldehyde yield compound 5 benzylidene - 3 - [2 - (2,3 - dihydro - 1 H benzimidazol - 2 - yl)phenyl] - 2 - imino - 1,3 - thiazolidin - 4 - one . The compounds were synthesizedin good yields and their structures were confirmed by IR, 1 H NMR - spectral dataand elemental analy sis. Antimicrobial activity against bacteria and fungi was studied. Investigation of antimicrobial activity of the compounds was done by disc diffusion method using Gram - positive ( S. aureus and B. subtilis ), Gram - negative ( E. coli , S. typhi ) bacteria. Some derivatives showed remarkable activity comparable to that of standard against Gram - positive and Gram - negative bacteria. The results of preliminary biological tests showed that of these compounds possess good biological activities.