Synthesis, characterization and molecular modeling of binuclear Pd(II) and Ir(IV) complexes with bis [4-hydroxy-6-methyl-3-{(1E)-N-[2-(ethylamino)ethyl]ethanimidoyl}-2H-pyran-2-one]: Application to detection of glucose

Abstract

Two binuclear Pd (II) and Ir(IV) complexes with new bis [4-hydroxy-6-methyl-3-{(1E)-N-[2-(ethylamino) ethyl] ethanimidoyl}-2H-pyran-2-one] ligand (Schiff base: L) have been prepared and characterized by elemental analysis, ESI-MS, conductivity, NMR (1H NMR, 13C NMR, COSY-NMR, HMBC-NMR and HSQC-NMR), EPR, FT-IR, ATR, UV–Visible spectra and cyclic voltammetry. Both antioxidant and antimicrobial activities were studied; the stability constants of the metal complexes and their interactions with glucose were estimated using spectrophotometric method. In addition, the detection of glucose using Pd(II) and Ir(IV) complexes was investigated using cavity microelectrode (CME) by chronoamperometric method.The characterization results and the molecular parameters were determined using DFT technique; a square planar geometry around Pd (II) and an octahedral geometry around Ir(IV) was found.The antioxidant measurements showed that the ligand and its complexes exhibited remarkable activity, and the antimicrobial studies revealed that all compounds are biologically active for some bacteria and fungi.Electrochemical measurements showed the presence of sensitive responses towards glucose using both Pd(II) and Ir(IV) complexes; these results were found to be higher than other materials around glucose concentration range of 0–4 mM.