Synthesis, Characterization and Molecular Docking Studies of Novel Pteridine Derivatives

Abstract

Pteridines are a group of heterocyclic compounds which contain nitrogen as a major heteroatom and it was aromatic compounds that are attached to the pyrazine and pyrimidine ring family. Pteridine derivatives have focused on a specific place in the medicinal chemistry field. The Pteridine ring is present in several natural compounds such as Pterin, Hemiptera (erythropoietin), Biopterin, Neopterin, Xanthopterin, iso-xanthopterin, etc., which include a few heterocyclic compounds like pyrimidine, pyrazine rings. Some vitamins like folic acid and riboflavin and drugs like methotrexate and triamterene. A pteridine is formed by a condensation process. A pteridine is frequently produced using costly and dangerous chemicals. In order to reduce the cost and consumption of hazardous chemicals, novel pteridine compounds were made by mixing a catalyst with a solvent, primary amines, and phenols. Currently, the primary issue limiting a medicine's ability to effectively treat a disease includes the development of resistance. In this article, we will utilise docking studies to provide a thorough explanation of the synthesis of pteridine derivatives and their antioxidant capabilities.