Synthesis, Characterization and Microbicides Activities of N-(hydroxy-4-((4-nitrophenyl)diazenyl)benzylidene)-2-(phenylamino)acetohydrazide metal complexes

Abstract

VO(II), Cu(II), Ni(II), Co(II), Mn(II), Fe(III), Ru(III) , Zn(II) and UO2(II) complexes of hydra-zone ligand containing azo group as side chain were prepared from condensation of 2-hydroxy-4-((4-nitrophenyl)diazenyl) benzylidene)benzaldehyde with 2-(phenyl amino)acetohydrazide. The ligand and its complexes were isolated in solid state and characterized by analytical techniques such as elemental analyses, molar conductance, magnetic susceptibility measurements and Electronic spin resonance (ESR) as well as spectroscopic techniques such as UV-Visible, IR, 1H-NMR and 13C- NMR. The spectral data indicated that the ligand acted as neutral bidentate or monobasic tridentate ligand bonded to the metal ions through an oxygen atom of ketonic or enolic carbonyl group, an azomethine nitrogen atom and deprotonated phenolic oxygen atom forming either tetragonally distorted octahedral or square planer geometry. ESR spectra of the solid metal complexes (2-6) and (8) were studied. Antimicrobial activities of the ligand and its complexes were evaluated against E. coli, Bacillus subtilis and Aspergillus Niger by well diffusion method. Results showed that the complex (10) exhibited higher antifungal activity, complex (7) exhibited higher antibacterial than the other complexes against E. coli, while complex (10) exhibited higher antibacterial against B.subtilis than the other complexes.