Synthesis, Characterization and Microbial Activity of Chiral Mixed Ligand Transition Metal Complexes

Abstract

Chiral mixed ligand (CML) metal complexes are synthesized by using isonitrosopropiophenone (HINPP) as a primary ligand and saccharides such as (+)-glucose and/or (-)-fructose as a chiral secondary ligand. The metal complexes have been characterized by elemental analysis and various physico-chemical techniques such as molar conductance, magnetic susceptibility, electronic absorption, infrared spectral studies and thermal analysis. Room temperature magnetic susceptibility measurements of these complexes are indicative of a tetrahedral and/or octahedral geometry. The molar conductance studies of the complexes indicate their non-electrolytic nature. Electronic absorption/reflectance spectra of the complexes show intra- ligand, charge transfer, and the d-d transitions, consistent with their proposed geometry. Thermal studies show the presence of lattice water in the complexes. The specific rotation of the complexes is due to the corresponding chiral saccharide moiety. The Paper Disc Diffusion method has been used to study the antibacterial activity of the compounds against some of the pathogenic bacteria such as C. diphtheriae, E. coli, S. typhi, S. dysenteriae, S. aureus and V. cholerae. The antifungal activity of the complexes against some of the pathogenic fungi such as Candida albicans and Aspergillus niger has been studied by tube dilution method. The results have been compared against those of controls, which were screened simultaneously. The complexes have been screened for acute oral toxicity in albino rats.