Synthesis, characterization and in vitro toxicity evaluation of doxorubicin-loaded magnetoliposomes on MCF-7 breast cancer cell line

Abstract

Nanoparticles improve the biodistribution and tumor accumulation of chemotherapeutic drugs boosting the ratio of efficacy and toxicity. One of the promising approaches in cancer treatment is the use of theranostic devices which enable simultaneous diagnosis and therapy of the disease. Recently, iron oxide nanoparticles have attracted increasing attention in cancer therapy, diagnosis, and smart drug delivery. This study is dedicated to introduce a modified coprecipitation method for the synthesis of magnetic iron oxide nanoparticle. Monodispersed biocompatible superparamagnetic iron oxide nanoparticles were successfully synthesized without any significant reduction in the saturation magnetization. The synthesized iron oxide nanoparticles and doxorubicin were passively encapsulated into PEGylated liposomes resulting in stable soluble magnetoliposomes with the size of about 100 nm. The cytotoxicity of doxorubicin loaded magnetoliposomes was investigated on MCF-7 cells.