Abstract
A novel drug carrier was synthesized through grafting polymerization of water-insoluble glucan from cotton cellulose tailored and polyoxyethylene oxide (PEO). By changing the molar ratio of water-insoluble glucan and ethylene oxide (EO), glucan-g-PEO copolymers with different chain lengths of PEO can be obtained. The physicochemical characteristics of docetaxel (DTX)-loaded glucan-g-PEO such as micro-morphology, size, critical micelle concentration (CMC), and in vitro release of kinetic were investigated. In vitro release profiles of docetaxel (DTX)-loaded glucan-g-PEO meet first-order release kinetics via a mechanism of diffusion and polymer chain relaxation. Another significant result is that release rates of DTX can be also modulated by changing the chain lengths of the PEO segments.
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