Synthesis, characterization and in vitro drug release of cisplatin loaded Cassava starch acetate–PEG/gelatin nanocomposites

Abstract

The aim of the present study is to examine the feasibility of Cassava starch acetate (CSA)–polyethylene glycol (PEG)–gelatin (G) nanocomposites as controlled drug delivery systems. It is one of the novel drug vehicles which can be used for the controlled release of an anticancer drug. Simple nano precipitation method was used to prepare the carriers CSA–PEG–G nanocomposites and they were used for entrapping cisplatin (CDDP). Through FT-IR spectroscopy, the linking among various components of the system was proved and with the help of scanning electron microscope and transmission electron microscopy (TEM), the surface morphology was investigated. The particle sizes of the CSA–CDDP, CSA–CDDP–PEG and CSA–CDDP–PEG–G polymer composites were between 140 and 350nm, as determined by a Zetasizer. Drug encapsulation efficiency, drug loading capacity and in vitro release of CDDP were evaluated respectively. The findings revealed that the cross linked CSA–PEG–G nanocomposites can be a potential polymeric carrier for controlled delivery of CDDP.