Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-chalcone hybrid molecules as Mycobacterium tuberculosis H37Rv inhibitors

Abstract

A novel series of 1,3,5-triazine-chalcone hybrid molecules (4a-ii) have been synthesized and evaluated in vitro for Mycobacterium tuberculosis H37Rv inhibitory potency using Alamar blue assay and the activity expressed as the minimum inhibitory concentration (MIC) in µg/mL. The antitubercular activity screening data revealed that the compound 4z demonstrated comparatively the most potent inhibitory activity, with MIC value 3.125 µg/mL. It is noteworthy that the compounds 4e, 4p and 4bb also showed appreciable inhibitory activity with MIC value 6.25 µg/mL. Most of the compounds displayed significantly promising activity and their structure-activity relationships were also discussed. This could be the remarkable starting point to develop new lead molecules with potential antitubercular activity.