Abstract
Three novel organotin(IV) complexes with 2-(9H-carbazol-9-yl) acetic acid ( HL), of the formulae {[ nBu 2SnOL] 2O} 2 ( 1), [ nBuSn(O)OL] 6 ( 2) and [ nBu 3SnOL] 6 ( 3) were prepared. All compounds were characterized by X-ray crystallography, confirming that complex ( 1) is tetranuclear one with ladder framework, complex ( 2) is a hexanuclear organotin(IV) complex with drum structure and complex ( 3) is a macrocycle with 24-membered stannoxane ring. Furthermore, all complexes were tested in vitro for their cytotoxic activity, using human hepatocellular carcinoma cell line (BEL-7402) and human hepatocellular liver carcinoma cell line (HepG2). Complex ( 1) displayed the best cytotoxicity and can be pointed out as a promising substrate to be subject of further investigations.
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