Abstract

Six new N-substituted di- and tributyltin 2-aminoethanethiolates (cysteaminates) have been prepared and characterised by 1H, 13C and 119Sn NMR spectroscopy. All these compounds exhibit a good in vitro antifungal effect against selected types of human pathogenic fungi (Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, Trichosporon beigelii, Aspergillus fumigatus, Absidia corymbifera, Trichophyton mentagrophytes) and their activity is comparable with that of some antifungal drugs commonly used in the clinical use like ketoconazole. The structure-activity relationships in these compounds are discussed.

Highlights

  • The organotin 2-aminoethanethiolates have been studied previously for their potential polydonor abilities

  • The lipophilic character of these derivatives seems to be no hamper for their antifungal effect

  • The results of in vitro antifungal susceptibility testing against eight strains of potentially pathogenic fungi for humans are given in Table as a minimal inhibitory concentration (MIC, in lamol.l)

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Summary

Introduction

The organotin 2-aminoethanethiolates (cysteaminates) have been studied previously for their potential polydonor abilities. Biological properties, especially antifungal effects, of these compounds The set of new butyltin derivatives containing N-substituted group SCH2CH2N has been prepared and their in vitro activity against some medically important yeasts (Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, Trichosporon beigelii) and molds (Aspergilhts fitmigatus, A bsidia cotymbifera, Trichophyton mentagrophytes) has been investigated. The studied compounds have been prepared by the reaction of tri- or dibutyltin chloride with corresponding N-substituted 2-aminoethanethiole in benzene solution in presence of natrium methoxide as a

Results
Conclusion

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