Synthesis, characterization and in vitro activity study of some organotin(IV) carboxylates against leukemia cancer cell, L-1210

Abstract

Abstract This paper presents successful resynthesizing of several dibutyl-, diphenyl-, and triphenyltin(IV) carboxylate compounds, and their activity against leukemia cancer cell, L-1210. The compounds were synthesized by reacting the dibutyltin(IV) oxide (DBTO) (1), diphenyltin(IV) oxide (DPTO) (3), and triphenyltin(IV) hydroxide (TPTOH) (5) with 3-hydroxybenzoic acid (3-HHBz). Prior to cancer activity tests, the compounds were characterized by UV–Vis, FT-IR, NMR (both 1H NMR and 13C NMR), and microanalysis to determine elemental composition of the samples. The anticancer tests revealed that triphenyltin(IV) 3-hydroxybenzoate (TPTHBz) (6) displayed significantly higher activity than those exhibited by dibutyltin(IV) di(3-hydroxybenzoate) (DBTHBz) (2) and diphenyltin(IV) di(3-hydroxybenzoate) (DPTHBz) (4).