Synthesis, characterization and fungicidal activity of novel 2-aminopyrimidine Schiff bases

Abstract

2-Aminopyrimidines represents vital class of bioactive molecules where its structural changes would lead to its peculiar properties. N -heterocyclic compound i.e. 2-aminopyrimidine had wide range of applications in pharmacological, material chemistry and agriculture as antifungal, antimicrobial and antibacterial agents. 2-Aminopyrimidine and its derivatives are good candidates for antimicrobial, antifungal and anticorrosion activity. In the present study, a series of substituted N -benzylidine-2-aminopyrimidine compounds have been synthesized by condensation reaction of 2-aminopyrimidine with substituted benzaldehydes ( o -chloro , m -hydroxybenzaldehyde, p -hydroxybenzaldehyde, 2,5-dimethoxybenzaldehyde, p -dimethylaminobenzaldehye, syringaldehyde, o -phthaldehyde, isovanillin benzaldehyde, veratraldehyde and thiophene-2-carboxyaldehyde) using glacial acetic acid or NaOH (40%). The synthesised Schiff bases have been characterized using UV, IR, 1 H NMR and 13 C spectral studies. 2-Aminopyrimidine Schiff bases ( 1-10 ) have been examined for fungitoxicity on the growth of Fusarium verticillioides , Rhizoctonia solani and Macrophomina phaseolina using poisoned food technique.