Abstract
Quinazolinone nucleus is a very attractive and useful scaffold in medicinal chemistry. It had been a pharmacophore in a wide variety of biologically active compounds. Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Prompted by therapeutic importance of quinazolinones and peptide derivatives, these two vital moieties were combined together into a single molecule by varying the different amino acids were synthesized, characterized and evaluated for anti-inflammatory and antimicrobial activities.
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