Synthesis, Characterization, and Evaluation of Antimicrobial and Antifertility Efficacy of Heterobimetallic Complexes of Copper (II)

Ashu Chaudhary,Anshul Singh

doi:10.1155/2017/5936465

Abstract

Heterobimetallic complexes of the copper with remarkable antimicrobial and antifertility action have been synthesized by the conventional method by reacting CuCl2 and o-phenylenediamine in the methanolic medium forming the mononuclear complex of the type CuC6H8N22Cl2 which was further treated with group 4 or 14 organometallic dichlorides (Ph2M′Cl2, Me2M′Cl2, and Cp2M′′Cl2) [M′ = Sn, Si, and M′′ = Ti, Zr] leading to formation of heterobimetallic complexes. All the synthesized complexes were characterized in the light of various physicochemical techniques like elemental analyses, conductivity measurements, molecular weight determination, electronic and infrared spectra, electronic spin resonance, X-ray, and mass spectral studies. The in vitro antibacterial activity of synthesized complexes against Escherichia coli and Staphylococcus aureus was tested to evaluate their inhibiting activities. The antifungal activities of mono- and heterobimetallic complexes were studied by screening the compounds against Fusarium oxysporum and Alternaria alternata. These complexes were then investigated to reveal their effect on the reproductive organs of male rats. The treatment has shown substantial decline in the sperm motility and density signifying the imperious antifertility activity.

Highlights

Over the past few decades, studies on heterobimetallic complexes have aroused as a conspicuous field in the quest for new chemistry because of their plausible applications in fundamental, applied sciences, and coordination chemistry beneficial in industrial and synthetic processes such as catalysis, photochemistry, and biological systems
Heterobimetallic complexes have gained augmented research interest in recent years owing to the presence of two different metals which contributes to captivating structures and results in imperative applications
Cupric chloride reacts with o-phenylenediamine leading to formation of mononuclear complex which on further treatment with organometallic dichlorides of group 4 or 14 resulted in formation of novel series of heterobimetallic complexes of copper

Summary

Introduction

Over the past few decades, studies on heterobimetallic complexes have aroused as a conspicuous field in the quest for new chemistry because of their plausible applications in fundamental, applied sciences, and coordination chemistry beneficial in industrial and synthetic processes such as catalysis, photochemistry, and biological systems. Bimetallic complexes encompassing two different metal centers have acknowledged escalated consideration owing to the assumption that their reactivity should vary significantly from that of monometallic complexes or homobimetallic complexes [1]. The physical properties of these complexes are greatly affected by the presence of two metals in the same molecule along with an appreciable change in their reactivity. This is due to the substantial modification in the individual properties of the metals or in the development of unique characteristics, which do not occur in monometallic compounds [2]. Varying applications of heterobimetallic complexes have been thoroughly explored which are found to be arising from the bifunctionality of the differing metal atoms [3]

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Results

Conclusion