Abstract
The aim of this research was to synthesize, characterize as well as to investigate the anti-inflammatory properties of Zn (II) and Cu (II) as the central atoms using acetaminophen as the complexing agent. Cu (II) and Zn (II) Complexes were synthesized and characterized by FTIR spectroscopy, UV- Visible Spectroscopy, X-Ray Diffraction Analysis, Melting Point and Conductivity Measurements. On the basis of this study, it is proven that Acetaminophen acts as a bidentate ligand coordinated to the metal ions through phenol and carbonyl oxygen atom. The acute toxic effect was carried out by the method and the rats were found to be moderately toxic and slightly toxic. The test complexes in general showed maximum inhibition percentage at about 3 hours, after 4 hours it goes on reducing and reaches a minimum at about 5 hours.
Highlights
The name Acetaminophen is gotten from the actual chemistry of the drug
As opposed to NonSteroidal anti-inflammatory drugs (NSAIDs), which reduce pain and inflammation by inhibiting Cyclooxygenase (COX) enzymes, Acetaminophen been shown to block the reuptake of endocannabinoids [2]
The reaction of Acetaminophen with the Zinc (II) chloride gave white solid complex and the reaction of Acetaminophen with copper (II) chloride gave brown solid complex According to the equations below
Summary
The name Acetaminophen is gotten from the actual chemistry of the drug. The chemical name of acetaminophen is para-acetyl aminophenol, and this is where acet-aminophen comes from. Scientists or medical professionals refer to acetaminophen by using Acetyl-para-aminophenol (APAP) [1]. Acetaminophen is a p-aminophenol derivative with analgesic and antipyretic activities. There are analgesics that are commonly associated with anti-inflammatory drugs but have no anti-inflammatory effects. As opposed to NonSteroidal anti-inflammatory drugs (NSAIDs), which reduce pain and inflammation by inhibiting Cyclooxygenase (COX) enzymes, Acetaminophen been shown to block the reuptake of endocannabinoids [2]
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