Synthesis, characterization and evaluation for antifungal activity of substituted diaryl imidazo [2, 1, b]-benzothiazole

Abstract

AimsTo synthesis substituted diaryl imidazole [2, 1, b] benzothiazole derivatives and evaluate for their antifungal activity. MethodThe synthesis of a series of substituted diaryl imidazo [2, 1-b] benzothiazole derivatives by reacting 2-amino benzothiazole with an appropriately substituted α-bromo-1,2-(p-substituted) diaryl-1-ethanones. All synthesized compounds were examined for their antifungal activity by disc diffusion method against pathogenic strains of Aspergillus flavus (MTCC 277), Aspergillus niger (MTCC 1344) and Candida albicans (MTCC 227) with the standard drug Clotrimazole. ResultsThe diaryl imidazo [2, 1-b] benzothiazole derivatives were synthesized and characterized by spectral studies using IR, 1H NMR, 13C NMR, Mass 1H NMR spectra (8a–y). All synthesized compounds examined for their antifungal activity and compounds 8k, 8l, 8m, 8n, 8q, 8r, and 8y exhibited excellent an antifungal activity profile as compared with the standard. ConclusionAll synthesized compounds showed mild to moderate activity against A. flavus and A. niger and this indicate that some of the newly synthesized title compounds exhibited promising antifungal activities and they warrant more consideration as prospective antimicrobials.